Science / Ingredients
The ingredient library
Every active, explained.
What each ingredient is, why it is in the sachet, the exact dose on the label, and links to the research.
- 35actives explained
- 5formulas
- 16studies linked
Every active, one library
Tap an ingredient to see what it is.
Plain-English notes, the exact dose on the label, which formulas contain it, and links to research where it exists.
Formula
Area of wellbeing
Showing 35 of 35 ingredients
What it is
Plentum's proprietary Heritage Probiotic Blend of named canine strains: L. casei K9-1, L. fermentum K9-2, L. brevis WF-1B and L. reuteri WF-1, plus S. boulardii in Gut Restore.
Why it is in the sachet
Adds live microbes to the gut ecosystem. It is the probiotic part of Gut Restore and Itch & Immune Care.
Dose per sachet (label)
- Gut Restore300 mg blend · L. casei K9-1, L. fermentum K9-2, L. brevis WF-1B, L. reuteri WF-1, S. boulardii · yielding 10 billion CFU
- Itch & Immune Care100 mg blend · L. casei K9-1, L. fermentum K9-2, L. brevis WF-1B, L. reuteri WF-1 · yielding 2 billion CFU
What it is
A probiotic yeast, not a bacterium, so it is not affected by antibiotics the way bacteria are.
Why it is in the sachet
Included in the blend for Gut Restore to support normal bowel function and stool consistency.
Dose per sachet (label)
- Gut RestoreIn the 300 mg probiotic blend (not listed separately)
Printed on the label as: Inside the probiotic blend
Research
- Effects of Saccharomyces boulardii Supplementation on Nutritional Status, Fecal Parameters, Microbiota, and Mycobiota in Breeding Adult Dogs.Meineri G et al. · 2022 · Veterinary sciences
What it is
A blend of three live probiotic strains: Lactobacillus reuteri PCR7, Lactobacillus helveticus and Bifidobacterium longum.
Why it is in the sachet
Sits next to the postbiotic in Calming Care to support the gut-brain axis.
Dose per sachet (label)
- Calming Care75 mg blend · L. reuteri PCR7, L. helveticus, B. longum · yielding 2 billion CFU
Printed on the label as: Proprietary Probiotic Blend (L. reuteri PCR7, L. helveticus, B. longum)
What it is
Two live probiotic species commonly found in the gut.
Why it is in the sachet
Supports a balanced gut flora and normal bowel function alongside the fibres in Metabolic Care.
Dose per sachet (label)
- Metabolic Care100 mg blend · B. animalis lactis, L. gasseri · yielding 2 billion CFU
Printed on the label as: Proprietary Probiotic Blend (B. animalis lactis, L. gasseri)
What it is
Heat-treated fermentation products of two bacteria, so it contains no live cultures.
Why it is in the sachet
Formulated to support a balanced oral microbiome and fresher breath as part of a dental-care routine.
Dose per sachet (label)
- Microbiome Care125 mg
Printed on the label as: Canine Oral Health Postbiotic (maltodextrin, dried Pediococcus pentosaceus and Bacillus subtilis fermentation products)
Research
- A Novel Postbiotic Reduces Canine Halitosis.Sordillo A et al. · 2025 · Animals
- Canine Halitosis Improved With a Postbiotic: A Validation Study.Sordillo A et al. · 2026 · Journal of veterinary dentistry
What it is
A non-living postbiotic made from fermented microbial material, in a powder.
Why it is in the sachet
Sits next to the probiotic blend in Calming Care and Itch & Immune Care to support the gut-brain and gut-skin axes.
Dose per sachet (label)
- Calming Care100 mg
- Itch & Immune Care250 mg
Printed on the label as: CIHP (Canine Immune Health Postbiotic)
What it is
A non-living postbiotic made from Pediococcus acidilactici.
Why it is in the sachet
Supports a balanced gut flora and gut pH in Metabolic Care, next to the probiotic blend.
Dose per sachet (label)
- Metabolic Care200 mg
Printed on the label as: Proprietary Postbiotic Blend (Pediococcus acidilactici)
What it is
The outer wall of baker's yeast, rich in mannans and beta-glucans. It is not alive.
Why it is in the sachet
Supports gut lining integrity and balanced gut flora during dietary change or stress.
Dose per sachet (label)
- Gut Restore75 mg
Printed on the label as: SafMannan (S. cerevisiae cell wall postbiotic)
What it is
A plant fibre from chicory or Jerusalem artichoke that gut bacteria ferment.
Why it is in the sachet
A prebiotic: it feeds the beneficial bacteria already living in the gut.
Dose per sachet (label)
- Microbiome Care100 mg
- Gut Restore50 mg (Jerusalem artichoke inulin)
Printed on the label as: Inulin · Jerusalem artichoke inulin
Research
- A dose-response experiment evaluating the effects of oligofructose and inulin on nutrient digestibility, stool quality, and fecal protein catabolites in healthy adult dogs.Propst EL et al. · 2003 · Journal of animal science
- Low-level fructan supplementation of dogs enhances nutrient digestion and modifies stool metabolite concentrations, but does not alter fecal microbiota populations.Barry KA et al. · 2009 · Journal of animal science
What it is
The husk of Plantago seeds. It forms a soft gel in water.
Why it is in the sachet
A soluble fibre that supports normal bowel function and healthy stool consistency.
Dose per sachet (label)
- Gut Restore200 mg
Research
What it is
Powdered inner bark of the slippery elm tree. It turns mucilaginous with water.
Why it is in the sachet
A traditional botanical used to support the gut lining.
Dose per sachet (label)
- Gut Restore150 mg
Printed on the label as: Slippery Elm Bark Powder
Good to know. If your dog takes medication, ask your vet about timing.
What it is
Dried pumpkin flesh, a familiar mild fibre.
Why it is in the sachet
Adds gentle fibre alongside psyllium and inulin to support healthy stool consistency.
Dose per sachet (label)
- Gut Restore150 mg
What it is
A soluble fibre from acacia tree gum that gut bacteria ferment slowly.
Why it is in the sachet
Supports normal bowel function and a balanced gut flora, and adds bulk without calories.
Dose per sachet (label)
- Metabolic Care175 mg
Printed on the label as: Acacia Fiber
What it is
Ground chia seed. It holds water, and brings fibre and plant omega-3 (ALA).
Why it is in the sachet
Adds fibre to the Metabolic Care blend to support normal bowel function.
Dose per sachet (label)
- Metabolic Care50 mg
What it is
Oil rich in the omega-3 fats EPA and DHA.
Why it is in the sachet
Omega-3s are structural parts of skin and cell membranes. They support skin and coat health and joint comfort.
Dose per sachet (label)
- Microbiome Care150 mg
Good to know. Fish-derived. Itch & Immune Care uses algal DHA instead.
Research
- A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement (Agepi® ω3) on clinical signs, and fatty acid concentrations in the erythrocyte membrane, hair shafts and skin surface of dogs with poor quality coats.Combarros D et al. · 2020 · Prostaglandins, leukotrienes, and essential fatty acids
What it is
DHA made by microalgae, the original source of the DHA that fish store.
Why it is in the sachet
A plant-based DHA that supports skin and coat health and a healthy, vibrant coat.
Dose per sachet (label)
- Itch & Immune Care250 mg
Printed on the label as: DHAGold (microalgae DHA, Schizochytrium sp.)
Research
- A prospective, randomized, double blind, placebo-controlled evaluation of the effects of an n-3 essential fatty acids supplement (Agepi® ω3) on clinical signs, and fatty acid concentrations in the erythrocyte membrane, hair shafts and skin surface of dogs with poor quality coats.Combarros D et al. · 2020 · Prostaglandins, leukotrienes, and essential fatty acids
- Microalgae Schizochytrium sp. as a source of docosahexaenoic acid (DHA): Effects on diet digestibility, oxidation and palatability and on immunity and inflammatory indices in dogs.Souza CMM et al. · 2019 · Animal science journal = Nihon chikusan Gakkaiho
What it is
The first milk from cows. It contains immunoglobulins and growth factors.
Why it is in the sachet
Supports the immune system and gut lining.
Dose per sachet (label)
- Microbiome Care100 mg
- Itch & Immune Care150 mg (30% IgG, bovine)
Printed on the label as: Colostrum Powder (Itch & Immune Care: 30% IgG, bovine)
Good to know. Bovine (dairy) source. Ask your vet first if your dog reacts to beef or dairy.
Research
- Supplementation of diets with bovine colostrum influences immune function in dogs.Satyaraj E et al. · 2013 · The British journal of nutrition
What it is
An amino acid that the cells lining the gut use as fuel.
Why it is in the sachet
Supports the gut barrier.
Dose per sachet (label)
- Microbiome Care100 mg
What it is
An amino acid found in tea leaves. It does not sedate.
Why it is in the sachet
Supports a calm and relaxed demeanor during situational stress, without drowsiness.
Dose per sachet (label)
- Calming Care200 mg
Printed on the label as: Suntheanine (L-theanine)
Research
- Therapy and Prevention of Noise Fears in Dogs-A Review of the Current Evidence for Practitioners.Riemer S et al. · 2023 · Animals
What it is
The main calming messenger in the nervous system.
Why it is in the sachet
Included to support relaxation during occasional stress.
Dose per sachet (label)
- Calming Care150 mg
Printed on the label as: GABA (gamma-aminobutyric acid)
What it is
An essential amino acid that the body uses to make serotonin.
Why it is in the sachet
Supports normal serotonin metabolism and balanced mood.
Dose per sachet (label)
- Calming Care100 mg
Research
- Therapy and Prevention of Noise Fears in Dogs-A Review of the Current Evidence for Practitioners.Riemer S et al. · 2023 · Animals
What it is
A nutrient that carries fatty acids into the cells' energy centres.
Why it is in the sachet
Supports normal fat metabolism as part of a weight-management routine.
Dose per sachet (label)
- Metabolic Care75 mg
What it is
Ground root of Glycyrrhiza, used in herbal traditions for centuries.
Why it is in the sachet
Included in small amounts as a traditional digestive-support botanical.
Dose per sachet (label)
- Microbiome Care50 mg
What it is
Dried chamomile flowers.
Why it is in the sachet
A traditional botanical for relaxation, in the Calming Care blend.
Dose per sachet (label)
- Calming Care75 mg
What it is
Dried aerial parts of Passiflora incarnata.
Why it is in the sachet
A traditional botanical for relaxation, in the Calming Care blend.
Dose per sachet (label)
- Calming Care75 mg
What it is
Ground root of Valeriana officinalis.
Why it is in the sachet
A traditional botanical for relaxation, in the Calming Care blend.
Dose per sachet (label)
- Calming Care50 mg
What it is
A root extract from an adaptogenic herb, standardised to at least 5% withanolides.
Why it is in the sachet
Supports normal cortisol levels during occasional stress.
Dose per sachet (label)
- Calming Care50 mg
Printed on the label as: KSM-66 Ashwagandha root extract (min. 5% withanolides)
What it is
A plant flavonoid found in onions, apples and capers.
Why it is in the sachet
Supports healthy cellular antioxidant activity and normal histamine metabolism.
Dose per sachet (label)
- Itch & Immune Care100 mg
What it is
A blue-green micro-alga rich in protein, pigments and antioxidants.
Why it is in the sachet
Supports healthy cellular antioxidant activity.
Dose per sachet (label)
- Itch & Immune Care75 mg
Research
- Supplementation of Diets With Spirulina Influences Immune and Gut Function in Dogs.Satyaraj E et al. · 2021 · Frontiers in nutrition
- Oral Palatability and Owners' Perception of the Effect of Increasing Amounts of Spirulina (Arthrospira platensis) in the Diet of a Cohort of Healthy Dogs and Cats.Stefanutti D et al. · 2023 · Animals
What it is
An extract of Phaseolus vulgaris beans that contains an alpha-amylase inhibitor.
Why it is in the sachet
Supports carbohydrate metabolism by modulating alpha-amylase activity.
Dose per sachet (label)
- Metabolic Care50 mg
Printed on the label as: White Kidney Bean Extract (Phaseolus vulgaris)
Good to know. Works alongside portion control and exercise, not instead of them.
What it is
A fibre-like polysaccharide made from the shells of crustaceans such as shrimp and crab.
Why it is in the sachet
Included as a fibre-type ingredient in the Metabolic Care blend.
Dose per sachet (label)
- Metabolic Care50 mg
Good to know. Shellfish-derived. Not for dogs with a shellfish allergy.
What it is
Zinc bound to the amino acid methionine, a form dogs absorb well.
Why it is in the sachet
An essential mineral for healthy skin, a shiny coat and normal immune function.
Dose per sachet (label)
- Microbiome Care5 mg
Printed on the label as: Zinc (Zinc Methionine)
Research
- Zinc in Dog Nutrition, Health and Disease: A Review.Pereira AM et al. · 2021 · Animals
What it is
Selenium bound to the amino acid methionine.
Why it is in the sachet
An essential trace mineral that supports antioxidant defences and thyroid function.
Dose per sachet (label)
- Microbiome Care20 mcg
Printed on the label as: Selenium (Selenomethionine)
Research
- Selenium and Dogs: A Systematic Review.Zentrichová V et al. · 2021 · Animals
What it is
A fat-soluble antioxidant vitamin.
Why it is in the sachet
Supports normal skin health and protects the omega-3 fats from oxidation.
Dose per sachet (label)
- Microbiome Care25 IU
Printed on the label as: Vitamin E (dl-alpha-tocopheryl acetate)
What it is
An essential mineral involved in nerve and muscle function.
Why it is in the sachet
Supports normal neurological function.
Dose per sachet (label)
- Calming Care100 mg
What it is
A B vitamin that the body needs to make serotonin and other messengers.
Why it is in the sachet
Supports normal neurological function and works with L-tryptophan.
Dose per sachet (label)
- Calming Care2 mg
Printed on the label as: Pyridoxine HCl (B6)
No ingredient matches.
Other ingredients on the printed labels of Gut Restore, Calming Care, Itch & Immune Care and Metabolic Care: brewer's yeast and silicon dioxide. Doses are per 2 g sachet. Dogs take 1 to 4 sachets a day by weight, so your dog's daily amount is the dose shown times the number of sachets.
Good to know.
Ask your vet first
Talk to your veterinarian before adding a supplement, especially if your dog takes medication, is pregnant or nursing, has a diagnosed condition, or has reacted to new foods. A supplement does not replace veterinary care.
The label is the source of truth
Doses on these pages are copied from the printed label for each formula. If a page and a pack ever differ, trust the pack and tell us through the contact page.