Quick answer
Choosing two supplements can be confusing when your dog has more than one concern.
Start with the main goal, then consider whether a second supplement adds a different kind of support.
The table below shows the available pairs; introduce them one at a time.
Why we made bundles
Your dog may need support for more than one part of their day.
Compare the pairs below, or use Match my dog to choose a starting point.
The bundles
| Bundle | Who it suits |
|---|---|
| Microbiome Care + Itch & Immune Care | A daily base plus seasonal skin and coat support. |
| Microbiome Care + Calming Care | A daily base plus support for stressful moments. |
| Microbiome Care + Gut Restore | Daily foundation plus additional digestive support. |
| Microbiome Care + Metabolic Care | Daily foundation alongside a vet-guided weight plan. |
| Gut Restore + Itch & Immune Care | A tummy that needs support, plus seasonal skin and coat. |
| Gut Restore + Calming Care | Digestive support alongside support for occasional stress. |
| Itch & Immune Care + Calming Care | Seasonal skin and coat, plus stressful moments. |
| Itch & Immune Care + Metabolic Care | Seasonal skin and coat, plus a healthy-weight plan. |
| Calming Care + Metabolic Care | Stressful moments, plus a healthy-weight plan. |
Choose the size of each supplement using your dog's current weight and its own label directions.
Two pairs worth a note
Microbiome Care + Gut Restore. These can be used together when both fit your dog's needs.
Our guide to Microbiome Care and Gut Restore explains their different roles.
Gut Restore + Metabolic Care.
We do not offer this pair as a bundle because their fiber and digestive-support roles overlap.
Discuss healthy weight management with your vet. Keep measured meals and exercise central to the plan.
Starting a two-supplement bundle
- Week 1Start the first supplement at half dose for 3 days.
- Week 1 onGive the full dose for your dog's weight.
-
After a full-dose week
Add the second supplement gradually. - DailyCount the total sachets for both.
How many sachets a day on two supplements
| Dog's weight | Microbiome Care + a targeted supplement | Two targeted supplements |
|---|---|---|
| 12 lb | 1 + 1 = 2 a day | 1 + 1 = 2 a day |
| 40 lb | 2 + 2 = 4 a day | 2 + 2 = 4 a day |
| 60 lb | 3 + 3 = 6 a day | 3 + 3 = 6 a day |
| 90 lb | 3 + 4 = 7 a day | 4 + 4 = 8 a day |
The total depends on both labels. The label directions show each weight band.
What stays the same in every bundle
The supplements in a bundle are the same products sold separately. Read both labels, including their cautions, before you start.

Three ways a pair might fit
- Seasonal skin and digestion: consider whether both concerns need support.
- Travel: plan for a familiar routine and discuss recurring digestive changes with your vet.
- Healthy weight: keep measured meals and exercise central to the plan.
Start with one, or both?
Start with one supplement so you can notice how your dog responds.
Our multiple-supplement guide covers combining products.
The daily supplement guide explains the foundation option.
Ask your vet first if
- Your dog takes any medicine, or has a health condition.
- Calming Care: your dog takes an MAOI, an SSRI, or trazodone.
- Metabolic Care: your dog is sensitive to shellfish (it contains chitosan).
- Itch & Immune Care: your dog reacts to dairy or beef (it contains bovine colostrum).
- All five supplements start at 12 weeks of age. Ask your vet before use during pregnancy or nursing.
Use Match my dog for help choosing. Our quality page explains how every lot is tested.
The supplements are the same in every row, so the choice comes down to timing and price.
| Option | How it works | Best fit |
|---|---|---|
| One supplement | Start with the moment that matters most | Owners who want a clear read first |
| A two-supplement bundle | Two supplements selected together in one order | Dogs with two overlapping moments |
| Two separate orders | Same supplements bought one at a time | Owners adding a second supplement later |
Frequently asked questions
How should I choose a bundle?
Use the table to match two distinct goals, and check both labels.
If one concern is new, persistent, or worsening, ask your vet about it before choosing supplements.
Do bundles change the supplements?
No. Each product keeps its own ingredients, weight-based directions, and cautions.
Should I start both supplements together?
Introduce one at a time using the sequence shown above. This makes changes easier to notice.
Can one bundle serve two dogs?
Choose each dog's supplements and sizes separately using their own weight and health history.
Sources
- Plentum Product Facts panels (amounts per 2 g sachet, directions, cautions) for all five supplements. Compare the supplements
- U.S. Food and Drug Administration. Animal food labeling and pet food claims. FDA
- Hill C, et al. Expert consensus document on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014. PubMed 24912386








